Zoloft is an antidepressant that is used to treat depression, generic for zoloft anxiety and obsessive compulsive disorder. It is a selective serotonin reuptake inhibitor (SSRI) which help to increase the amount of serotonin available in the brain. generic for zoloft produces fewer side effects than older antidepressants called tricyclics, such as Elavil and Tofranil.